diff --git a/drivers/tty/Kconfig b/drivers/tty/Kconfig
index 341abaed4ce2..bdd267dbd5e4 100644
--- a/drivers/tty/Kconfig
+++ b/drivers/tty/Kconfig
@@ -222,7 +222,7 @@ config MOXA_INTELLIO
 
 config MOXA_SMARTIO
 	tristate "Moxa SmartIO support v. 2.0"
-	depends on SERIAL_NONSTANDARD && PCI
+	depends on SERIAL_NONSTANDARD && PCI && HAS_IOPORT
 	help
 	  Say Y here if you have a Moxa SmartIO multiport serial card and/or
 	  want to help develop a new version of this driver.
@@ -303,7 +303,7 @@ config GOLDFISH_TTY_EARLY_CONSOLE
 
 config IPWIRELESS
 	tristate "IPWireless 3G UMTS PCMCIA card support"
-	depends on PCMCIA && NETDEVICES
+	depends on PCMCIA && NETDEVICES && HAS_IOPORT
 	select PPP
 	help
 	  This is a driver for 3G UMTS PCMCIA card from IPWireless company. In
diff --git a/drivers/tty/serial/8250/8250_early.c b/drivers/tty/serial/8250/8250_early.c
index 0ebde0ab8167..4192b1ae2736 100644
--- a/drivers/tty/serial/8250/8250_early.c
+++ b/drivers/tty/serial/8250/8250_early.c
@@ -48,8 +48,10 @@ static unsigned int serial8250_early_in(struct uart_port *port, int offset)
 		return readl(port->membase + offset);
 	case UPIO_MEM32BE:
 		return ioread32be(port->membase + offset);
+#ifdef CONFIG_HAS_IOPORT
 	case UPIO_PORT:
 		return inb(port->iobase + offset);
+#endif
 	case UPIO_AU:
 		return port->serial_in(port, reg_offset);
 	default:
@@ -75,9 +77,11 @@ static void serial8250_early_out(struct uart_port *port, int offset, int value)
 	case UPIO_MEM32BE:
 		iowrite32be(value, port->membase + offset);
 		break;
+#ifdef CONFIG_HAS_IOPORT
 	case UPIO_PORT:
 		outb(value, port->iobase + offset);
 		break;
+#endif
 	case UPIO_AU:
 		port->serial_out(port, reg_offset, value);
 		break;
diff --git a/drivers/tty/serial/8250/8250_pci.c b/drivers/tty/serial/8250/8250_pci.c
index c55be6fda0ca..70bd84a05da7 100644
--- a/drivers/tty/serial/8250/8250_pci.c
+++ b/drivers/tty/serial/8250/8250_pci.c
@@ -847,6 +847,7 @@ static int pci_netmos_init(struct pci_dev *dev)
 	return num_serial;
 }
 
+#ifdef CONFIG_HAS_IOPORT
 /*
  * These chips are available with optionally one parallel port and up to
  * two serial ports. Unfortunately they all have the same product id.
@@ -973,6 +974,7 @@ static void pci_ite887x_exit(struct pci_dev *dev)
 	ioport &= 0xffff;
 	release_region(ioport, ITE_887x_IOSIZE);
 }
+#endif /* CONFIG_HAS_IOPORT */
 
 /*
  * Oxford Semiconductor Inc.
@@ -1255,6 +1257,7 @@ static int pci_asix_setup(struct serial_private *priv,
 #define QOPR_CLOCK_X8		0x0003
 #define QOPR_CLOCK_RATE_MASK	0x0003
 
+#ifdef CONFIG_HAS_IOPORT
 /* Quatech devices have their own extra interface features */
 static struct pci_device_id quatech_cards[] = {
 	{ PCI_DEVICE_DATA(QUATECH, QSC100,   1) },
@@ -1474,6 +1477,7 @@ static int pci_quatech_setup(struct serial_private *priv,
 		pci_warn(priv->dev, "software control of RS422 features not currently supported.\n");
 	return pci_default_setup(priv, board, port, idx);
 }
+#endif /* CONFIG_HAS_IOPORT */
 
 static int pci_default_setup(struct serial_private *priv,
 		  const struct pciserial_board *board,
@@ -1753,6 +1757,7 @@ static int skip_tx_en_setup(struct serial_private *priv,
 	return pci_default_setup(priv, board, port, idx);
 }
 
+#ifdef CONFIG_HAS_IOPORT
 static void kt_handle_break(struct uart_port *p)
 {
 	struct uart_8250_port *up = up_to_u8250p(p);
@@ -1796,6 +1801,7 @@ static int kt_serial_setup(struct serial_private *priv,
 	port->port.handle_break = kt_handle_break;
 	return skip_tx_en_setup(priv, board, port, idx);
 }
+#endif /* CONFIG_HAS_IOPORT */
 
 static int pci_eg20t_init(struct pci_dev *dev)
 {
@@ -1840,6 +1846,7 @@ pci_wch_ch38x_setup(struct serial_private *priv,
 #define CH384_XINT_ENABLE_REG   0xEB
 #define CH384_XINT_ENABLE_BIT   0x02
 
+#ifdef CONFIG_HAS_IOPORT
 static int pci_wch_ch38x_init(struct pci_dev *dev)
 {
 	int max_port;
@@ -1867,6 +1874,7 @@ static void pci_wch_ch38x_exit(struct pci_dev *dev)
 	iobase = pci_resource_start(dev, 0);
 	outb(0x0, iobase + CH384_XINT_ENABLE_REG);
 }
+#endif /* CONFIG_HAS_IOPORT */
 
 
 static int
@@ -2070,6 +2078,7 @@ static struct pci_serial_quirk pci_serial_quirks[] = {
 		.subdevice	= PCI_ANY_ID,
 		.setup		= ce4100_serial_setup,
 	},
+#ifdef CONFIG_HAS_IOPORT
 	{
 		.vendor		= PCI_VENDOR_ID_INTEL,
 		.device		= PCI_DEVICE_ID_INTEL_PATSBURG_KT,
@@ -2089,6 +2098,7 @@ static struct pci_serial_quirk pci_serial_quirks[] = {
 		.setup		= pci_default_setup,
 		.exit		= pci_ite887x_exit,
 	},
+#endif
 	/*
 	 * National Instruments
 	 */
@@ -2210,6 +2220,7 @@ static struct pci_serial_quirk pci_serial_quirks[] = {
 		.exit		= pci_ni8430_exit,
 	},
 	/* Quatech */
+#ifdef CONFIG_HAS_IOPORT
 	{
 		.vendor		= PCI_VENDOR_ID_QUATECH,
 		.device		= PCI_ANY_ID,
@@ -2218,6 +2229,7 @@ static struct pci_serial_quirk pci_serial_quirks[] = {
 		.init		= pci_quatech_init,
 		.setup		= pci_quatech_setup,
 	},
+#endif
 	/*
 	 * Panacom
 	 */
@@ -2588,6 +2600,7 @@ static struct pci_serial_quirk pci_serial_quirks[] = {
 		.subdevice      = PCI_ANY_ID,
 		.setup          = pci_wch_ch38x_setup,
 	},
+#ifdef CONFIG_HAS_IOPORT
 	/* WCH CH384 8S card (16850 clone) */
 	{
 		.vendor         = PCIE_VENDOR_ID_WCH,
@@ -2598,6 +2611,7 @@ static struct pci_serial_quirk pci_serial_quirks[] = {
 		.exit		= pci_wch_ch38x_exit,
 		.setup          = pci_wch_ch38x_setup,
 	},
+#endif
 	/*
 	 * ASIX devices with FIFO bug
 	 */
diff --git a/drivers/tty/serial/8250/8250_port.c b/drivers/tty/serial/8250/8250_port.c
index fe8d79c4ae95..8d8606dc763b 100644
--- a/drivers/tty/serial/8250/8250_port.c
+++ b/drivers/tty/serial/8250/8250_port.c
@@ -401,6 +401,7 @@ static void au_serial_dl_write(struct uart_8250_port *up, int value)
 
 #endif
 
+#ifdef CONFIG_HAS_IOPORT
 static unsigned int hub6_serial_in(struct uart_port *p, int offset)
 {
 	offset = offset << p->regshift;
@@ -414,6 +415,7 @@ static void hub6_serial_out(struct uart_port *p, int offset, int value)
 	outb(p->hub6 - 1 + offset, p->iobase);
 	outb(value, p->iobase + 1);
 }
+#endif /* CONFIG_HAS_IOPORT */
 
 static unsigned int mem_serial_in(struct uart_port *p, int offset)
 {
@@ -463,6 +465,7 @@ static unsigned int mem32be_serial_in(struct uart_port *p, int offset)
 	return ioread32be(p->membase + offset);
 }
 
+#ifdef CONFIG_HAS_IOPORT
 static unsigned int io_serial_in(struct uart_port *p, int offset)
 {
 	offset = offset << p->regshift;
@@ -474,6 +477,24 @@ static void io_serial_out(struct uart_port *p, int offset, int value)
 	offset = offset << p->regshift;
 	outb(value, p->iobase + offset);
 }
+#endif
+static unsigned int no_serial_in(struct uart_port *p, int offset)
+{
+	return (unsigned int)-1;
+}
+
+static void no_serial_out(struct uart_port *p, int offset, int value)
+{
+}
+
+#ifdef CONFIG_HAS_IOPORT
+static inline bool is_upf_fourport(struct uart_port *port)
+{
+	return port->flags & UPF_FOURPORT;
+}
+#else
+#define is_upf_fourport(x)	false
+#endif
 
 static int serial8250_default_handle_irq(struct uart_port *port);
 
@@ -485,10 +506,12 @@ static void set_io_from_upio(struct uart_port *p)
 	up->dl_write = default_serial_dl_write;
 
 	switch (p->iotype) {
+#ifdef CONFIG_HAS_IOPORT
 	case UPIO_HUB6:
 		p->serial_in = hub6_serial_in;
 		p->serial_out = hub6_serial_out;
 		break;
+#endif
 
 	case UPIO_MEM:
 		p->serial_in = mem_serial_in;
@@ -519,10 +542,17 @@ static void set_io_from_upio(struct uart_port *p)
 		break;
 #endif
 
-	default:
+#ifdef CONFIG_HAS_IOPORT
+	case UPIO_PORT:
 		p->serial_in = io_serial_in;
 		p->serial_out = io_serial_out;
 		break;
+#endif
+
+	default:
+		WARN(1, "Unsupported UART type %x\n", p->iotype);
+		p->serial_in = no_serial_in;
+		p->serial_out = no_serial_out;
 	}
 	/* Remember loaded iotype */
 	up->cur_iotype = p->iotype;
@@ -1379,7 +1409,7 @@ static void autoconfig_irq(struct uart_8250_port *up)
 	unsigned long irqs;
 	int irq;
 
-	if (port->flags & UPF_FOURPORT) {
+	if (is_upf_fourport(port)) {
 		ICP = (port->iobase & 0xfe0) | 0x1f;
 		save_ICP = inb_p(ICP);
 		outb_p(0x80, ICP);
@@ -1398,7 +1428,7 @@ static void autoconfig_irq(struct uart_8250_port *up)
 	irqs = probe_irq_on();
 	serial8250_out_MCR(up, 0);
 	udelay(10);
-	if (port->flags & UPF_FOURPORT) {
+	if (is_upf_fourport(port)) {
 		serial8250_out_MCR(up, UART_MCR_DTR | UART_MCR_RTS);
 	} else {
 		serial8250_out_MCR(up,
@@ -1416,7 +1446,7 @@ static void autoconfig_irq(struct uart_8250_port *up)
 	serial8250_out_MCR(up, save_mcr);
 	serial_out(up, UART_IER, save_ier);
 
-	if (port->flags & UPF_FOURPORT)
+	if (is_upf_fourport(port))
 		outb_p(save_ICP, ICP);
 
 	if (uart_console(port))
@@ -2381,7 +2411,7 @@ int serial8250_do_startup(struct uart_port *port)
 	serial_port_out(port, UART_LCR, UART_LCR_WLEN8);
 
 	spin_lock_irqsave(&port->lock, flags);
-	if (up->port.flags & UPF_FOURPORT) {
+	if (is_upf_fourport(&up->port)) {
 		if (!up->port.irq)
 			up->port.mctrl |= TIOCM_OUT1;
 	} else
@@ -2463,7 +2493,7 @@ int serial8250_do_startup(struct uart_port *port)
 	 */
 	up->ier = UART_IER_RLSI | UART_IER_RDI;
 
-	if (port->flags & UPF_FOURPORT) {
+	if (is_upf_fourport(port)) {
 		unsigned int icp;
 		/*
 		 * Enable interrupts on the AST Fourport board
@@ -2506,7 +2536,7 @@ void serial8250_do_shutdown(struct uart_port *port)
 		serial8250_release_dma(up);
 
 	spin_lock_irqsave(&port->lock, flags);
-	if (port->flags & UPF_FOURPORT) {
+	if (is_upf_fourport(port)) {
 		/* reset interrupts on the AST Fourport board */
 		inb((port->iobase & 0xfe0) | 0x1f);
 		port->mctrl |= TIOCM_OUT1;
diff --git a/drivers/tty/serial/8250/Kconfig b/drivers/tty/serial/8250/Kconfig
index 5313aa31930f..2a43bea7d7c3 100644
--- a/drivers/tty/serial/8250/Kconfig
+++ b/drivers/tty/serial/8250/Kconfig
@@ -6,7 +6,6 @@
 
 config SERIAL_8250
 	tristate "8250/16550 and compatible serial support"
-	depends on !S390
 	select SERIAL_CORE
 	select SERIAL_MCTRL_GPIO if GPIOLIB
 	help
@@ -72,7 +71,7 @@ config SERIAL_8250_16550A_VARIANTS
 
 config SERIAL_8250_FINTEK
 	bool "Support for Fintek F81216A LPC to 4 UART RS485 API"
-	depends on SERIAL_8250
+	depends on SERIAL_8250 && HAS_IOPORT
 	help
 	  Selecting this option will add support for the RS485 capabilities
 	  of the Fintek F81216A LPC to 4 UART.
@@ -160,7 +159,7 @@ config SERIAL_8250_HP300
 
 config SERIAL_8250_CS
 	tristate "8250/16550 PCMCIA device support"
-	depends on PCMCIA && SERIAL_8250
+	depends on PCMCIA && SERIAL_8250 && HAS_IOPORT
 	help
 	  Say Y here to enable support for 16-bit PCMCIA serial devices,
 	  including serial port cards, modems, and the modem functions of
diff --git a/drivers/tty/serial/Kconfig b/drivers/tty/serial/Kconfig
index 398e5aac2e77..dc41b3be6800 100644
--- a/drivers/tty/serial/Kconfig
+++ b/drivers/tty/serial/Kconfig
@@ -871,7 +871,7 @@ config SERIAL_TXX9_STDSERIAL
 
 config SERIAL_JSM
 	tristate "Digi International NEO and Classic PCI Support"
-	depends on PCI
+	depends on PCI && HAS_IOPORT
 	select SERIAL_CORE
 	help
 	  This is a driver for Digi International's Neo and Classic series
