diff --git a/drivers/tty/Kconfig b/drivers/tty/Kconfig
index a45d423ad10f02c3a818021bbb18655a8b690500..63a494d36a1fdceba5a7b39f4516060e48af0cc6 100644
--- a/drivers/tty/Kconfig
+++ b/drivers/tty/Kconfig
@@ -220,7 +220,7 @@ config MOXA_INTELLIO
 
 config MOXA_SMARTIO
 	tristate "Moxa SmartIO support v. 2.0"
-	depends on SERIAL_NONSTANDARD && PCI
+	depends on SERIAL_NONSTANDARD && PCI && HAS_IOPORT
 	help
 	  Say Y here if you have a Moxa SmartIO multiport serial card and/or
 	  want to help develop a new version of this driver.
@@ -302,7 +302,7 @@ config GOLDFISH_TTY_EARLY_CONSOLE
 
 config IPWIRELESS
 	tristate "IPWireless 3G UMTS PCMCIA card support"
-	depends on PCMCIA && NETDEVICES
+	depends on PCMCIA && NETDEVICES && HAS_IOPORT
 	select PPP
 	help
 	  This is a driver for 3G UMTS PCMCIA card from IPWireless company. In
diff --git a/drivers/tty/serial/8250/8250_early.c b/drivers/tty/serial/8250/8250_early.c
index 6176083d0341ca10edebe5c4eebfffc922a61472..84242292176570cd2c92afbd4755d303827a4abc 100644
--- a/drivers/tty/serial/8250/8250_early.c
+++ b/drivers/tty/serial/8250/8250_early.c
@@ -46,8 +46,10 @@ static unsigned int serial8250_early_in(struct uart_port *port, int offset)
 		return readl(port->membase + offset);
 	case UPIO_MEM32BE:
 		return ioread32be(port->membase + offset);
+#ifdef CONFIG_HAS_IOPORT
 	case UPIO_PORT:
 		return inb(port->iobase + offset);
+#endif
 	default:
 		return 0;
 	}
@@ -70,9 +72,11 @@ static void serial8250_early_out(struct uart_port *port, int offset, int value)
 	case UPIO_MEM32BE:
 		iowrite32be(value, port->membase + offset);
 		break;
+#ifdef CONFIG_HAS_IOPORT
 	case UPIO_PORT:
 		outb(value, port->iobase + offset);
 		break;
+#endif
 	}
 }
 
diff --git a/drivers/tty/serial/8250/8250_pci.c b/drivers/tty/serial/8250/8250_pci.c
index 6709b6a5f3011db38acc58dc7223158fe4fcf72e..7d7a6d62c09ceabcf4094d539c565ed09c153561 100644
--- a/drivers/tty/serial/8250/8250_pci.c
+++ b/drivers/tty/serial/8250/8250_pci.c
@@ -964,6 +964,9 @@ static int pci_ite887x_init(struct pci_dev *dev)
 	struct resource *iobase = NULL;
 	u32 miscr, uartbar, ioport;
 
+	if (!IS_ENABLED(CONFIG_HAS_IOPORT))
+		return serial_8250_warn_need_ioport(dev);
+
 	/* search for the base-ioport */
 	for (i = 0; i < ARRAY_SIZE(inta_addr); i++) {
 		iobase = request_region(inta_addr[i], ITE_887x_IOSIZE,
@@ -1514,6 +1517,9 @@ static int pci_quatech_init(struct pci_dev *dev)
 	const struct pci_device_id *match;
 	bool amcc = false;
 
+	if (!IS_ENABLED(CONFIG_HAS_IOPORT))
+		return serial_8250_warn_need_ioport(dev);
+
 	match = pci_match_id(quatech_cards, dev);
 	if (match)
 		amcc = match->driver_data;
@@ -1538,6 +1544,9 @@ static int pci_quatech_setup(struct serial_private *priv,
 		  const struct pciserial_board *board,
 		  struct uart_8250_port *port, int idx)
 {
+	if (!IS_ENABLED(CONFIG_HAS_IOPORT))
+		return serial_8250_warn_need_ioport(priv->dev);
+
 	/* Needed by pci_quatech calls below */
 	port->port.iobase = pci_resource_start(priv->dev, FL_GET_BASE(board->flags));
 	/* Set up the clocking */
@@ -1655,6 +1664,9 @@ static int pci_fintek_setup(struct serial_private *priv,
 	u8 config_base;
 	u16 iobase;
 
+	if (!IS_ENABLED(CONFIG_HAS_IOPORT))
+		return serial_8250_warn_need_ioport(pdev);
+
 	config_base = 0x40 + 0x08 * idx;
 
 	/* Get the io address from configuration space */
@@ -1686,6 +1698,9 @@ static int pci_fintek_init(struct pci_dev *dev)
 	u8 config_base;
 	struct serial_private *priv = pci_get_drvdata(dev);
 
+	if (!IS_ENABLED(CONFIG_HAS_IOPORT))
+		return serial_8250_warn_need_ioport(dev);
+
 	if (!(pci_resource_flags(dev, 5) & IORESOURCE_IO) ||
 			!(pci_resource_flags(dev, 4) & IORESOURCE_IO) ||
 			!(pci_resource_flags(dev, 3) & IORESOURCE_IO))
@@ -1864,6 +1879,9 @@ static int kt_serial_setup(struct serial_private *priv,
 			   const struct pciserial_board *board,
 			   struct uart_8250_port *port, int idx)
 {
+	if (!IS_ENABLED(CONFIG_HAS_IOPORT))
+		return serial_8250_warn_need_ioport(priv->dev);
+
 	port->port.flags |= UPF_BUG_THRE;
 	port->port.serial_in = kt_serial_in;
 	port->port.handle_break = kt_handle_break;
@@ -1884,6 +1902,9 @@ pci_wch_ch353_setup(struct serial_private *priv,
 		    const struct pciserial_board *board,
 		    struct uart_8250_port *port, int idx)
 {
+	if (!IS_ENABLED(CONFIG_HAS_IOPORT))
+		return serial_8250_warn_need_ioport(priv->dev);
+
 	port->port.flags |= UPF_FIXED_TYPE;
 	port->port.type = PORT_16550A;
 	return pci_default_setup(priv, board, port, idx);
@@ -1894,6 +1915,9 @@ pci_wch_ch355_setup(struct serial_private *priv,
 		const struct pciserial_board *board,
 		struct uart_8250_port *port, int idx)
 {
+	if (!IS_ENABLED(CONFIG_HAS_IOPORT))
+		return serial_8250_warn_need_ioport(priv->dev);
+
 	port->port.flags |= UPF_FIXED_TYPE;
 	port->port.type = PORT_16550A;
 	return pci_default_setup(priv, board, port, idx);
@@ -1904,6 +1928,9 @@ pci_wch_ch38x_setup(struct serial_private *priv,
 		    const struct pciserial_board *board,
 		    struct uart_8250_port *port, int idx)
 {
+	if (!IS_ENABLED(CONFIG_HAS_IOPORT))
+		return serial_8250_warn_need_ioport(priv->dev);
+
 	port->port.flags |= UPF_FIXED_TYPE;
 	port->port.type = PORT_16850;
 	return pci_default_setup(priv, board, port, idx);
@@ -1918,6 +1945,8 @@ static int pci_wch_ch38x_init(struct pci_dev *dev)
 	int max_port;
 	unsigned long iobase;
 
+	if (!IS_ENABLED(CONFIG_HAS_IOPORT))
+		return serial_8250_warn_need_ioport(dev);
 
 	switch (dev->device) {
 	case 0x3853: /* 8 ports */
@@ -1937,6 +1966,11 @@ static void pci_wch_ch38x_exit(struct pci_dev *dev)
 {
 	unsigned long iobase;
 
+	if (!IS_ENABLED(CONFIG_HAS_IOPORT)) {
+		serial_8250_warn_need_ioport(dev);
+		return;
+	}
+
 	iobase = pci_resource_start(dev, 0);
 	outb(0x0, iobase + CH384_XINT_ENABLE_REG);
 }
@@ -2052,6 +2086,9 @@ static int pci_moxa_init(struct pci_dev *dev)
 	unsigned int i, num_ports = moxa_get_nports(device);
 	u8 val, init_mode = MOXA_RS232;
 
+	if (!IS_ENABLED(CONFIG_HAS_IOPORT))
+		return serial_8250_warn_need_ioport(dev);
+
 	if (!(pci_moxa_supported_rs(dev) & MOXA_SUPP_RS232)) {
 		init_mode = MOXA_RS422;
 	}
@@ -2084,6 +2121,9 @@ pci_moxa_setup(struct serial_private *priv,
 	unsigned int bar = FL_GET_BASE(board->flags);
 	int offset;
 
+	if (!IS_ENABLED(CONFIG_HAS_IOPORT))
+		return serial_8250_warn_need_ioport(priv->dev);
+
 	if (board->num_ports == 4 && idx == 3)
 		offset = 7 * board->uart_offset;
 	else
diff --git a/drivers/tty/serial/8250/8250_pcilib.c b/drivers/tty/serial/8250/8250_pcilib.c
index ea906d721b2c3eac15c9e8d62cc6fa56c3ef6150..ec4d041778027a0c9f27facbb97c2b74819cfda3 100644
--- a/drivers/tty/serial/8250/8250_pcilib.c
+++ b/drivers/tty/serial/8250/8250_pcilib.c
@@ -12,6 +12,14 @@
 #include "8250.h"
 #include "8250_pcilib.h"
 
+int serial_8250_warn_need_ioport(struct pci_dev *dev)
+{
+	dev_warn(&dev->dev,
+		 "Serial port not supported because of missing I/O resource\n");
+
+	return -ENXIO;
+}
+
 int serial8250_pci_setup_port(struct pci_dev *dev, struct uart_8250_port *port,
 		   u8 bar, unsigned int offset, int regshift)
 {
@@ -27,12 +35,14 @@ int serial8250_pci_setup_port(struct pci_dev *dev, struct uart_8250_port *port,
 		port->port.mapbase = pci_resource_start(dev, bar) + offset;
 		port->port.membase = pcim_iomap_table(dev)[bar] + offset;
 		port->port.regshift = regshift;
-	} else {
+	} else if (IS_ENABLED(CONFIG_HAS_IOPORT)) {
 		port->port.iotype = UPIO_PORT;
 		port->port.iobase = pci_resource_start(dev, bar) + offset;
 		port->port.mapbase = 0;
 		port->port.membase = NULL;
 		port->port.regshift = 0;
+	} else {
+		return serial_8250_warn_need_ioport(dev);
 	}
 	return 0;
 }
diff --git a/drivers/tty/serial/8250/8250_pcilib.h b/drivers/tty/serial/8250/8250_pcilib.h
index 1aaf1b50ce9cc9d78c098e0495838c17eb8752cd..16a274574cdef938fe7700d30b19e75dbbd9b748 100644
--- a/drivers/tty/serial/8250/8250_pcilib.h
+++ b/drivers/tty/serial/8250/8250_pcilib.h
@@ -13,3 +13,5 @@ struct uart_8250_port;
 
 int serial8250_pci_setup_port(struct pci_dev *dev, struct uart_8250_port *port, u8 bar,
 		   unsigned int offset, int regshift);
+
+int serial_8250_warn_need_ioport(struct pci_dev *dev);
diff --git a/drivers/tty/serial/8250/8250_port.c b/drivers/tty/serial/8250/8250_port.c
index 3509af7dc52b8816f2f5ab58f0d999696f7483e7..91369f542b0bc7fc1d044f24db9a4ac98b394660 100644
--- a/drivers/tty/serial/8250/8250_port.c
+++ b/drivers/tty/serial/8250/8250_port.c
@@ -338,6 +338,7 @@ static void default_serial_dl_write(struct uart_8250_port *up, u32 value)
 	serial_out(up, UART_DLM, value >> 8 & 0xff);
 }
 
+#ifdef CONFIG_HAS_IOPORT
 static unsigned int hub6_serial_in(struct uart_port *p, int offset)
 {
 	offset = offset << p->regshift;
@@ -351,6 +352,7 @@ static void hub6_serial_out(struct uart_port *p, int offset, int value)
 	outb(p->hub6 - 1 + offset, p->iobase);
 	outb(value, p->iobase + 1);
 }
+#endif /* CONFIG_HAS_IOPORT */
 
 static unsigned int mem_serial_in(struct uart_port *p, int offset)
 {
@@ -400,6 +402,7 @@ static unsigned int mem32be_serial_in(struct uart_port *p, int offset)
 	return ioread32be(p->membase + offset);
 }
 
+#ifdef CONFIG_HAS_IOPORT
 static unsigned int io_serial_in(struct uart_port *p, int offset)
 {
 	offset = offset << p->regshift;
@@ -411,6 +414,15 @@ static void io_serial_out(struct uart_port *p, int offset, int value)
 	offset = offset << p->regshift;
 	outb(value, p->iobase + offset);
 }
+#endif
+static unsigned int no_serial_in(struct uart_port *p, int offset)
+{
+	return (unsigned int)-1;
+}
+
+static void no_serial_out(struct uart_port *p, int offset, int value)
+{
+}
 
 static int serial8250_default_handle_irq(struct uart_port *port);
 
@@ -422,10 +434,12 @@ static void set_io_from_upio(struct uart_port *p)
 	up->dl_write = default_serial_dl_write;
 
 	switch (p->iotype) {
+#ifdef CONFIG_HAS_IOPORT
 	case UPIO_HUB6:
 		p->serial_in = hub6_serial_in;
 		p->serial_out = hub6_serial_out;
 		break;
+#endif
 
 	case UPIO_MEM:
 		p->serial_in = mem_serial_in;
@@ -446,11 +460,16 @@ static void set_io_from_upio(struct uart_port *p)
 		p->serial_in = mem32be_serial_in;
 		p->serial_out = mem32be_serial_out;
 		break;
-
-	default:
+#ifdef CONFIG_HAS_IOPORT
+	case UPIO_PORT:
 		p->serial_in = io_serial_in;
 		p->serial_out = io_serial_out;
 		break;
+#endif
+	default:
+		WARN(1, "Unsupported UART type %x\n", p->iotype);
+		p->serial_in = no_serial_in;
+		p->serial_out = no_serial_out;
 	}
 	/* Remember loaded iotype */
 	up->cur_iotype = p->iotype;
@@ -1174,7 +1193,7 @@ static void autoconfig(struct uart_8250_port *up)
 		 */
 		scratch = serial_in(up, UART_IER);
 		serial_out(up, UART_IER, 0);
-#ifdef __i386__
+#if defined(__i386__) && defined(CONFIG_HAS_IOPORT)
 		outb(0xff, 0x080);
 #endif
 		/*
@@ -1183,7 +1202,7 @@ static void autoconfig(struct uart_8250_port *up)
 		 */
 		scratch2 = serial_in(up, UART_IER) & UART_IER_ALL_INTR;
 		serial_out(up, UART_IER, UART_IER_ALL_INTR);
-#ifdef __i386__
+#if defined(__i386__) && defined(CONFIG_HAS_IOPORT)
 		outb(0, 0x080);
 #endif
 		scratch3 = serial_in(up, UART_IER) & UART_IER_ALL_INTR;
diff --git a/drivers/tty/serial/8250/Kconfig b/drivers/tty/serial/8250/Kconfig
index 47ff50763c048c89b19b7c9f13f462bc5368ab43..afa75020d132de2210545fbe54e0d03df4b72a41 100644
--- a/drivers/tty/serial/8250/Kconfig
+++ b/drivers/tty/serial/8250/Kconfig
@@ -6,7 +6,6 @@
 
 config SERIAL_8250
 	tristate "8250/16550 and compatible serial support"
-	depends on !S390
 	select SERIAL_CORE
 	select SERIAL_MCTRL_GPIO if GPIOLIB
 	help
@@ -72,7 +71,7 @@ config SERIAL_8250_16550A_VARIANTS
 
 config SERIAL_8250_FINTEK
 	bool "Support for Fintek variants"
-	depends on SERIAL_8250
+	depends on SERIAL_8250 && HAS_IOPORT
 	help
 	  Selecting this option will add support for the RS232 and RS485
 	  capabilities of the Fintek F81216A LPC to 4 UART as well similar
@@ -163,7 +162,7 @@ config SERIAL_8250_HP300
 
 config SERIAL_8250_CS
 	tristate "8250/16550 PCMCIA device support"
-	depends on PCMCIA && SERIAL_8250
+	depends on PCMCIA && SERIAL_8250 && HAS_IOPORT
 	help
 	  Say Y here to enable support for 16-bit PCMCIA serial devices,
 	  including serial port cards, modems, and the modem functions of
diff --git a/drivers/tty/serial/Kconfig b/drivers/tty/serial/Kconfig
index 28e4beeabf8f373fc76e09ea7d1c9d55a66f4964..45f0f779fbf960e9fa66375dbc44c379edc63bef 100644
--- a/drivers/tty/serial/Kconfig
+++ b/drivers/tty/serial/Kconfig
@@ -877,7 +877,7 @@ config SERIAL_TXX9_STDSERIAL
 
 config SERIAL_JSM
 	tristate "Digi International NEO and Classic PCI Support"
-	depends on PCI
+	depends on PCI && HAS_IOPORT
 	select SERIAL_CORE
 	help
 	  This is a driver for Digi International's Neo and Classic series
diff --git a/include/linux/serial_core.h b/include/linux/serial_core.h
index 4ab65874a850b4402ca3a7d3bdda597d7d5093f9..743b4afaad4c89a6028e592be2cae2643614c89b 100644
--- a/include/linux/serial_core.h
+++ b/include/linux/serial_core.h
@@ -505,7 +505,11 @@ struct uart_port {
 	 * The remaining bits are serial-core specific and not modifiable by
 	 * userspace.
 	 */
+#ifdef CONFIG_HAS_IOPORT
 #define UPF_FOURPORT		((__force upf_t) ASYNC_FOURPORT       /* 1  */ )
+#else
+#define UPF_FOURPORT		0
+#endif
 #define UPF_SAK			((__force upf_t) ASYNC_SAK            /* 2  */ )
 #define UPF_SPD_HI		((__force upf_t) ASYNC_SPD_HI         /* 4  */ )
 #define UPF_SPD_VHI		((__force upf_t) ASYNC_SPD_VHI        /* 5  */ )
